Breeding Strategy and Advice

Possible Results of PLL Testing

* Clear/Normal: This finding indicates the gene is not present in your dog. Therefore, when used for breeding, a Clear dog will not pass on the disease gene.

Carrier: This finding indicates one copy of the disease gene is present in your dog, but it will mot exhibit disease symptoms. Carriers will not have medical problems as a result. Dogs with Carrier status can be enjoyed without the fear of developing medical problems but will pass on the disease gene 50% of the time.

Affected: This finding indicates two copies of the disease gene are present in the dog. Unfortunately, the dog will be medically affected by the disease. Appropriate treatment should be pursued by consulting a veterinarian.

* Please Note: Some sites and some breeders use the word Normal or Clear. Both these words mean the same thing. It means the dog in question is NOT a Carrier nor is it Affected.

Additionally, the wording "Cleared By Parentage" or CBP means both sire and dam are proven Normal/Clear and that pair bred together will never produce an Affected or Carrier offspring.

Breeding Strategy Advice

Source: Animal Health Trust

(a globally respected animal research charity organization in the UK which dissolved during the COVID-19 pandemic, not to be confused with a DNA testing company currently operating under the same name)

Our research has demonstrated the frequency of the PLL mutation is extremely high in the PLL-Affected breeds that we have studied in depth. This means that allowing only CLEAR dogs to breed could have a devastating effect on breed diversity and substantially increase the likelihood of new inherited diseases emerging. Therefore, we strongly advise breeders to consider all their dogs for breeding, regardless of their PLL genotype. GENETICALLY AFFECTED and CARRIER dogs can be bred with, but should only be bred to DNA tested, CLEAR dogs. All puppies from any litter that has at least one CARRIER parent should be DNA tested, so that the CARRIERS can be identified and followed clinically throughout their lives. This practice should be followed for at least one or two generations, to allow the PLL mutation to be slowly eliminated from the population without severely reducing the genetic diversity of breeds at risk.

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